LONAFARNIB (loe na far nib) treats certain types of genetic disorders such as Hutchinson-Gilford progeria syndrome. It is not a cure.

ZOKINVY Lifestyle Interactions

  • Lonafarnib 50mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Severe
    • Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Lonafarnib together without talking to your health care provider. Taking these together may increase the risk of serious side effects.
    • Notes for Professionals: Advise patients to avoid grapefruit juice or grapefruit-containing foods during treatment with lonafarnib; concurrent use may increase the exposure of lonafarnib and the risk of adverse effects. Lonafarnib is a sensitive CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased the exposure of lonafarnib by 425%.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.