ST. JOHNS WORT

St. John's Wort (Hypericum Perforatum) 300mg, Oral capsule

Alcohol

· Severity: Mild

· Notes for Consumers: You may feel drowsy or more tired when taking alcohol with St. John's wort. Do not drive or operate machinery until you know how this drug-herb combination affects you. You may wish to limit your intake of alcoholic beverages while on this herb.

· Notes for Professionals: Since some compounds in St. John's wort may potentially inhibit MAO, and some beverages that contain ethanol may contain tyramine, it may be prudent to avoid concomitant use of alcohol and St. John's Wort.

St. John's Wort (Hypericum Perforatum) 300mg, Oral capsule

Tyramine-containing foods

· Severity: Mild

· Notes for Consumers: Food interactions with St. John's Wort are thought to be unlikely. You may wish to limit your intake of alcoholic beverages, aged or smoked meats, or aged cheeses while on this herb as a precaution, but there is no evidence to suggest this is necessary. St. John's wort may also decrease the actions of Caffeine, but serious interactions are not expected.

· Notes for Professionals: Since some compounds in St. John's wort may potentially inhibit MAO, the ingestion of tyramine-containing foods, like aged or smoked meats, yeast, cheeses, pickled herring, should be minimized when using St. John's wort.

St. John's Wort (Hypericum Perforatum) 300mg, Oral capsule

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be decreased if combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with St. John's wort, Hypericum perforatum. St. John's wort is an inducer of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with St. John's wort, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be increased. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>