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SPIRONOLACTONE; HYDROCHLOROTHIAZIDE (speer on oh LAK tone; hye droe klor oh THYE a zide) is a combination of 2 diuretics. It helps you make more urine and to lose salt and excess water from your body. It treats swelling from heart, kidney, or liver disease. It also treats high blood pressure.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this drug by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.
Talk to your health care provider about the use of this drug in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medicine with any of the following medications:
-cidofovir
-eplerenone
-tranylcypromine
This medicine may also interact with the following medications:
-aspirin
-certain medicines for blood pressure, heart disease like benazepril, lisinopril, losartan, valsartan
-certain medicines that treat or prevent blood clots like heparin and enoxaparin
-cholestyramine
-cyclosporine
-digoxin
-lithium
-medicines that relax muscles for surgery
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-other diuretics
-potassium supplements
-steroid medicines like prednisone or cortisone
-trimethoprim
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor what your blood pressure should be, and when you should contact them.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
You must not get dehydrated. Ask your doctor or health care professional how much fluid you need to drink a day. Check with him or her if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Talk to your health care professional about your risk of skin cancer. You may be more at risk for skin cancer if you take this medicine.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
-black or tarry stools
-changes in vision
-difficulty breathing
-eye pain
-fast, irregular heartbeat
-feeling faint or dizzy
-fever
-gout pain
-muscle pain, cramps
-numbness, tingling in hands or feet
-redness, blistering, peeling or loosening of the skin, including inside the mouth
-signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.
-trouble passing urine
-unusual bleeding
-unusually weak
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-breast enlargement in both males and females
-change in sex drive or performance
-constipation
-dry mouth
-headache
-irregular menstrual periods
-stomach upset, nausea
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused drug after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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