SODIUM OXYBATE (Generic for XYREM)

Sodium Oxybate (Gamma Hydroxybutyrate Or Ghb) 0.5g/1mL, Oral solution

Alcohol

· Severity: Severe

· Notes for Consumers: Do not drink Alcoholic beverages while taking this medication. This combination will cause mental and physical impairment. Serious side effects such as confusion, loss of coordination, muscle twitching or weakness, sweating, tremor, seizures, or difficulty breathing. You must not drive or operate machinery, including flying an airplane or other tasks, for 6 hours after you have taken a dose of this medicine.

· Notes for Professionals: Ethanol is contraindicated in patients using sodium oxybate or other oxybates. Dangerous, additive CNS depressant effects are possible, including respiratory depression. Patients should be strongly warned against the use of any alcoholic beverages in conjunction with oxybates.

Sodium Oxybate (Gamma Hydroxybutyrate Or Ghb) 0.5g/1mL, Oral solution

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking this medication. Also avoid medicines containing additional Caffeine whenever possible. Side effects from these drugs may be additive. Taking a high amount of Caffeine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects.

· Notes for Professionals: Caffeine should be avoided or used cautiously with oxybates. Monitor for potential side effects such as nervousness, irritability, insomnia, and/or cardiac arrhythmias.

Sodium Oxybate (Gamma Hydroxybutyrate Or Ghb) 0.5g/1mL, Oral solution

Food

· Severity: Moderate

· Notes for Consumers: You must take the first dose of this medicine each night at bedtime while in bed and at least 2 hours after eating any food. You should eat your evening foods and take your medicine at roughly the same times each night to avoid interactions.

· Notes for Professionals: Oxybates should be administered on an empty stomach. Patients should administer their first bedtime dose at least 2 hours after eating and take their bedtime dosages at a consistent time in relation to meals each night. Food significantly decreases the bioavailability of sodium oxybate and other oxybates.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>