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RITUXIMAB; HYALURONIDASE (ri TUX i mab / hye al ur ON i dase) is used to treat non-Hodgkin lymphoma and chronic lymphocytic leukemia. Rituximab is a monoclonal antibody. Hyaluronidase is used to improve the effects of rituximab.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting.
A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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This medicine may interact with the following medications:
-cisplatin
-live virus vaccines
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medicine. You may need blood work done while you are taking this medicine.
This medicine can cause serious allergic reactions. To reduce your risk you may need to take medicine before treatment with this medicine. Take your medicine as directed.
In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your doctor right away. If you cannot reach your doctor, urgently seek other source of medical care.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Do not become pregnant while taking this medicine or for 12 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for at least 6 months after stopping it.
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It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives; swelling of the face, lips, or tongue
-breathing problems
-chest pain
-changes in vision
-diarrhea
-dizziness
-headache with fever, neck stiffness, sensitivity to light, nausea, or confusion
-fast, irregular heartbeat
-loss of memory
-low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
-mouth sores
-problems with balance, talking, or walking
-redness, blistering, peeling or loosening of the skin, including inside the mouth
-signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
-signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-stomach pain
-swelling of the ankles, feet, hands
-unusual bleeding or bruising
-vomiting
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-headache
-joint pain
-muscle cramps or muscle pain
-nausea
-pain, redness, or irritation at site where injected
-tiredness
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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