RETEVMO

SELPERCATINIB (SEL per KA ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat certain kinds of lung and thyroid cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Swallow the capsules whole. You can take it with or without food. If it upsets your stomach, take it with food. If you are also taking certain medicines for stomach problems like lansoprazole, omeprazole, or pantoprazole, take it with food. Do not take with grapefruit juice. Talk to your pharmacist about when to take your medicines. Some medicines must be separated from this one by several hours. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
 
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

Do not take this medicine with any of the following medications:
-cisapride
-dronedarone
-pimozide
-thioridazine
 
This medicine may also interact with the following medications:
-certain antibiotics like erythromycin or clarithromycin
-certain antivirals for HIV or hepatitis
-certain medicines for fungal infections like ketoconazole, itraconazole, or posaconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-diltiazem
-grapefruit juice
-other medicines that prolong the QT interval (an abnormal heart rhythm)
-repaglinide
-St. John's Wort
-stomach acid blockers like cimetidine, famotidine, ranitidine, lansoprazole, omeprazole, or pantoprazole
-verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse.
 
You may need blood work done while you are taking this medicine.
 
If you are going to need surgery or other procedure, tell your health care professional that you are using this medicine.
 
Do not become pregnant while taking this medicine or for 1 week after stopping it. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 week after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care professional for more information.
 
Do not breast-feed a child while taking this medicine or for 1 week after stopping it.
 
This medicine may increase your risk to bruise or bleed. Call your health care professional if you notice any unusual bleeding.
 
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care professional if the problem does not go away or is severe.
 
This medicine may increase your risk of getting an infection. Call your health care professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
 
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care professional. These medicines may hide a fever.
 
This medicine has caused ovarian failure in some women. This medicine may make it more difficult to get pregnant. Talk to your health care professional if you are concerned about your fertility.
 
This medicine has caused decreased sperm counts in some men. This may make it more difficult to father a child. Talk to your health care professional if you are concerned about your fertility.

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 6 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breathing problems
-nausea, vomiting
-signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose
-signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast, irregular heartbeat; palpitations; feeling faint or lightheaded; falls; breathing problems
-signs and symptoms of infection like fever; chills; cough; sore throat; pain or trouble passing urine
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
 
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-constipation
-cough
-diarrhea
-dry mouth
-headache
-rash
-swelling of the ankles, feet, hands
-weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children.
 
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.