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RELION ALL-IN-ONE Lifestyle Interactions
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Temsirolimus 25mg/1mL, Solution for injection
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not take Temsirolimus with Grapefruit Juice. Grapefruit Juice may increase the levels of Temsirolimus in your body and side effects from Temsirolimus may be worse.• Notes for Professionals: Avoid consumption of grapefruit or grapefruit juice with temsirolimus due to increased plasma concentrations of the primary active metabolite of temsirolimus (sirolimus). Temsirolimus is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor did not significantly affect temsirolimus exposure, but increased the AUC and Cmax of sirolimus by 3.1-fold and 2.2-fold, respectively.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
