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PRO-CEPTION FERTILITY PAK Lifestyle Interactions
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Darolutamide 300mg, Oral tablet
• Interaction: Grapefruit juice• Severity: Moderate• Notes for Consumers: Talk to your doctor or healthcare professional about your grapefruit intake while receiving Darolutamide. Grapefruit may increase Darolutamide levels, causing side effects to get worse including tiredness, rash, and pain in your arms or legs. Tell your health care professional about any new or unusual side effects.• Notes for Professionals: Inform patients that darolutamide-related adverse reactions may increase if they consume grapefruit/grapefruit juice. Grapefruit is a P-glycoprotein (P-gp) inhibitor and a strong CYP3A4 inhibitor; darolutamide is a CYP3A4 substrate. Concomitant use with another combined P-gp inhibitor and strong CYP3A4 inhibitor increased the mean AUC and Cmax of darolutamide by 1.7-fold and 1.4-fold, respectively.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
