• Image of Prempro medication

    • PREMPRO

    • QTY 28
    • 0.3-1.5MG
    • Tablet

CONJUGATED ESTROGENS; MEDROXYPROGESTERONE (CON ju gate ed  ESS troe jenz; me DROX ee proe JES te rone) is used as hormone replacement in menopausal women who still have their uterus. This medicine helps to treat hot flashes and prevent osteoporosis (weak bones).

PREMPRO Lifestyle Interactions

  • Conjugated Estrogens 0.3mg, Medroxyprogesterone Acetate 1.5mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take these drugs together without approval from your prescriber. Taking these drugs together can increase side effects from Medroxyprogesterone. Discuss any new or worsening side effects with your health care provider.
    • Notes for Professionals: Coadministration of medroxyprogesterone, a CYP3A substrate with grapefruit juice, a strong CYP3A inhibitor should be avoided since it is expected to increase concentrations of medroxyprogesterone acetate. Formal drug interaction studies have not been conducted; however, medroxyprogesterone is metabolized primarily by hydroxylation via the CYP3A4 in vitro.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.