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POSACONAZOLE (POE sa KON a zole) is an antifungal medicine. It is used to prevent certain kinds of fungal or yeast infections.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medicine by mouth. Take it as directed on the prescription label at the same time every day. Do not cut, crush or chew this medicine. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.
Talk to your health care provider about the use of this medicine in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medicine with any of the following medications:
-certain medicines for cholesterol like atorvastatin, lomitapide, lovastatin, simvastatin
-certain medicines for irregular heart beat like dronedarone, quinidine
-cisapride
-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
-ibrutinib
-lapatinib
-naloxegol
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-pimozide
-sirolimus
-thioridazine
This medicine may also interact with the following medications:
-certain antivirals for HIV or hepatitis
-certain medicines for anxiety or sleep like alprazolam, midazolam, triazolam
-certain medicines for blood pressure like diltiazem, nifedipine, nicardipine, verapamil
-certain medicines for cancer like venetoclax, vinblastine, vincristine
-certain medicines for diabetes like glipizide
-certain medicines for seizures like phenytoin
-digoxin
-dofetilide
-medicines that lower your chance of fighting infection like cyclosporine, tacrolimus
-metoclopramide
-other medicines for fungal infections
-rifabutin
-ziprasidone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse. You may need blood work while you are taking this medicine.
If you get severe diarrhea or vomiting tell your health care provider right away. You may not get your full dose of medicine if you are sick.
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If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions (skin rash, itching or hives; swelling of the face, lips, or tongue)
-diarrhea and/or vomiting
-fever
-heartbeat rhythm changes (trouble breathing; chest pain; dizziness; fast, irregular heartbeat; feeling faint or lightheaded, falls)
-liver injury (dark yellow or brown urine; general ill feeling or flu-like symptoms; loss of appetite, right upper belly pain; unusually weak or tired, yellowing of the eyes or skin, light-colored stool)
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-cough
-headache
-nausea
-stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:
-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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