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LUMACAFTOR; IVACAFTOR (LOO ma KAF tor; EYE va KAF tor) treats cystic fibrosis (CF). It works by improving the function of a protein in your body, which helps balance the level of salt and water in the lungs. This prevents mucus from building up in your lungs, which may improve symptoms of CF. It is not a cure for CF.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with fat-containing foods such as eggs, avocados, nuts, butter, peanut butter, or cheese pizza. Breast milk, infant formula, whole-milk dairy products (such as whole milk, cheese, and yogurt) may also be used. Take it as directed on the prescription label. Keep taking it unless your care team tells you to stop.
Do not take this medication with grapefruit juice.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 years of age for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Artemether; lumefantrine
-Boceprevir
-Cobicistat; elvitegravir; emtricitabine; tenofovir
-Cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide
-Dasabuvir; ombitasvir; paritaprevir; ritonavir
-Emtricitabine; rilpivirine; tenofovir
-Lurasidone
-Nifedipine
-Ombitasvir; paritaprevir; ritonavir
-Praziquantel
-Ranolazine
-Rilpivirine
This medication may also interact with the following:
-Certain antibiotics like clarithromycin, erythromycin, telithromycin
-Certain medications for depression, anxiety, or sleep
-Certain medications for diabetes, like glipizide or repaglinide
-Certain medications for immunosuppression like cyclosporine, everolimus, sirolimus, or tacrolimus
-Certain medications for seizures like carbamazepine, phenobarbital, phenytoin
-Certain medications for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-Certain medications for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-Digoxin
-Female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-Grapefruit juice
-Ibuprofen
-Montelukast
-Rifabutin
-Rifampin
-St. John's Wort
-Steroid medications like prednisone or methylprednisolone
-Warfarin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
This medication may cause cataracts, especially in children. You should have regular eye exams while taking this medication. Tell your care team if you have changes in your eyesight.
Estrogen and/or progestin hormones may not work as well while you are taking this medication. If you are using this medication for contraception, talk to your care team about using a second type of contraception. A barrier contraceptive, such as a condom or diaphragm, is recommended.
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If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 6 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Change in vision
-Increase in blood pressure
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Shortness of breath or chest pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Diarrhea
-Gas
-Fatigue
-Headache
-Irregular menstrual cycles or spotting
-Nausea
-Stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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