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ONDANSETRON (on DAN se tron) prevents nausea and vomiting from chemotherapy, radiation, or surgery. It works by blocking substances in the body that may cause nausea or vomiting. It belongs to a group of medications called antiemetics.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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These tablets are made to dissolve in the mouth. Do not try to push the tablet through the foil backing. With dry hands, peel away the foil backing and gently remove the tablet. Place the tablet in the mouth and allow it to dissolve, then swallow. While you may take these tablets with water, it is not necessary to do so.
Talk to your care team regarding the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Apomorphine
-Certain medications for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-Cisapride
-Dronedarone
-Pimozide
-Thioridazine
This medication may also interact with the following:
-Carbamazepine
-Certain medications for depression, anxiety, or psychotic disturbances
-Fentanyl
-Linezolid
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-Methylene blue (injected into a vein)
-Other medications that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
-Phenytoin
-Rifampicin
-Tramadol
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Check with your care team as soon as you can if you have any sign of an allergic reaction.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Bowel blockage—stomach cramping, unable to have a bowel movement or pass gas, loss of appetite, vomiting
-Chest pain (angina)—pain, pressure, or tightness in the chest, neck, back, or arms
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Constipation
-Diarrhea
-General discomfort and fatigue
-Headache
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store between 2 and 30 degrees C (36 and 86 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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