OLANZAPINE-FLUOXETINE HCL (Generic for SYMBYAX)

Olanzapine 6mg, Fluoxetine Hydrochloride 25mg, Oral capsule

Marijuana

· Severity: Major

· Notes for Consumers: Avoid this combination. It may cause your condition to get worse. Marijuana may also decrease the efficacy of this medicine, making it not work as well for you. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice unusual changes in moods or behaviors of any type.

· Notes for Professionals: It is recommended that patients avoid the use of marijuana, by any route, if they are treated for a psychiatric history, including psychosis and bipolar disorder, as the cannabinoids (the psychoactive ingredients, such as THC) in marijuana can produce psychotoxic effects and may exacerbate psychiatric disorders. A high frequency of use and use of products with high-potency of THC are potential risk factors for psychiatric effects. Additive CNS effects, such as sedation or CNS depression are also possible. Clinical studies suggest that cannabis use may reduce the efficacy of some antipsychotic drugs. In addition, several cannabinoids in marijuana appear to influence the activity of CYP enzymes and P-glycoprotein, which may alter the concentrations of antipsychotics and influence either safety or efficacy.

Olanzapine 6mg, Fluoxetine Hydrochloride 25mg, Oral capsule

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoke may decrease the effectiveness of Olanzapine by increasing the elimination of Olanzapine from the body. If you smoke tobacco, notify your prescriber if you experience changes in mood (like agitation or hearing or seeing things that are not really there) that may indicate that Olanzapine is not working as well for you. If you suddenly stop smoking tobacco, this may increase the actions of Olanzapine; notify your prescriber if you notice increased drowsiness, dizziness or other unusual side effects.

· Notes for Professionals: Tobacco smoking causes a substantial reduction in plasma concentrations of olanzapine. Although tobacco smokers might require higher doses of olanzapine, dosage modifications are not routinely recommended due to the wide therapeutic index of olanzapine.

Olanzapine 6mg, Fluoxetine Hydrochloride 25mg, Oral capsule

Alcohol

· Severity: Moderate

· Notes for Consumers: Limit alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Alcohol may potentiate the CNS effects of the atypical antipsychotics, which have the potential to cause increased sedation or to impair judgment, thinking, or motor skills. Patients should be appropriately cautioned; some manufacturers recommend alcohol avoidance during treatment.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>