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DONEPEZIL; MEMANTINE (doe NEP e zil; MEM an teen) treats memory loss and confusion (dementia) in people who have Alzheimer disease. It works by improving attention, memory, and the ability to engage in daily activities. It is not a cure for dementia or Alzheimer disease.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with a glass of water. Follow the directions on the prescription label. You may take this medication with or without food. Swallow the capsules whole. Do not chew or crush. If swallowing is difficult, you may open the capsules and sprinkle the entire contents on cool applesauce before swallowing. Take your doses at regular intervals. Do not take your medication more often than directed. Continue to take your medication even if you feel better. Do not stop taking except on the advice of your care team.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Certain medications for fungal infections like itraconazole, fluconazole, posaconazole, and voriconazole
-Cisapride
-Dextromethorphan; quinidine
-Dronedarone
-Pimozide
-Quinidine
-Thioridazine
This medication may also interact with the following:
-Acetazolamide
-Antihistamines for allergy, cough and cold
-Atropine
-Bethanechol
-Carbamazepine
-Certain medications for bladder problems like oxybutynin, tolterodine
-Certain medications for Parkinson's disease like benztropine, trihexyphenidyl
-Certain medications for stomach problems like dicyclomine, hyoscyamine
-Certain medications for travel sickness like scopolamine
-Cimetidine
-Dexamethasone
-Dofetilide
-Hydrochlorothiazide (HCTZ)
-Ketamine
-Ipratropium
-Metformin
-Methazolamide
-Nicotine
-NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen
-Other medications for Alzheimer's disease
-Other medications that prolong the QT interval (cause an abnormal heart rhythm)
-Phenobarbital
-Phenytoin
-Ranitidine
-Rifampin, rifabutin or rifapentine
-Sodium bicarbonate
-Succinylcholine
-Triamterene
-Ziprasidone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Check with your care team if there is no improvement in your symptoms or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.
If you are going to need surgery or other procedure, tell your care team that you are using this medication.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you do not take your medication for several days, contact your care team. Your dose may need to be changed.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Peptic ulcer—burning stomach pain, loss of appetite, bloating, burping, heartburn, nausea, vomiting
-Seizures
-Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
-Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds
-Trouble passing urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Diarrhea
-Dizziness
-Headache
-Loss of appetite
-Nausea
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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