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NALOXEGOL (nal OX e GAHL) is used to treat constipation caused by opioids (pain medicine). Tell your health care professional if you stop taking your opioid pain medicine.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow medicine whole. Do not cut or chew this medicine. The medicine may also be crushed and mixed with 4 ounces of water. Drink immediately after mixing. Take your medicine one time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal. If you are unable to tolerate your dose, inform your healthcare provider so that your dose can be adjusted. Do not take additional laxatives except on your healthcare provider's advice. Your healthcare provider may prescribe other laxatives if your medicine does not work well enough after 3 days of treatment. Tell your healthcare provider if you stop taking your pain medicine. If you stop taking your pain medicine, you should also stop taking this medicine. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medicine with any of the following medications:
-certain antiviral medicines for HIV or AIDS
-certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
-chloramphenicol
-clarithromycin
-dalfopristin; quinupristin
-idelalisib
-mifepristone
-nefazodone
-telithromycin
This medicine may also interact with the following medications:
-bevacizumab
-carbamazepine
-diltiazem
-erythromycin
-grapefruit juice
-methylnaltrexone
-naloxone
-naltrexone
-rifampin
-St. John's Wort
-verapamil
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your doctor for regular check ups. Tell your doctor if your symptoms do not get better or if they get worse. If you develop unusually persistent or worsening abdominal pain, stop taking your medicine and seek medical attention.
You may have symptoms of opioid withdrawal during treatment with this medicine. Symptoms include sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning. Tell your health care provider if you have any of these symptoms. Also, if you take methadone to treat your pain, you may be more likely to have stomach pain and diarrhea compared to people who do not take methadone. If you take too much of this medicine, call your healthcare provider or go to the nearest emergency room right away.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-new or worsening stomach pain
-severe or prolonged diarrhea
-signs and symptoms of opioid withdrawal such as sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-diarrhea
-headache
-nausea
-stomach gas
-stomach pain
-vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law. Follow the directions in the MedGuide.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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