LYBALVI

OLANZAPINE; SAMIDORPHAN (oh LAN za peen; SAM i DOR fan) is used to treat schizophrenia and bipolar disorder. Bipolar disorder is also known as manic-depression.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

Take this medicine by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush or chew this medicine. Swallow the capsules whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your health care provider about the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

Do not take this medicine with any of the following medications:
-dronedarone
-cisapride
-narcotic medicines for pain, cough, or drug use disorders
-pimozide
-thioridazine
This medicine may also interact with the following medications:
-alcohol
-antihistamines for allergy, cough, and cold
-atropine
-carbamazepine
-certain medicines for anxiety or sleep
-certain medicines for bladder problems like oxybutynin, tolterodine
-certain medicines for depression
-certain medicines for fungal infections, like itraconazole, ketoconazole
-certain medicines for Parkinson's disease like levodopa, benztropine, trihexyphenidyl
-certain medicines for stomach problems like dicyclomine, hyoscyamine
-certain medicines for travel sickness like scopolamine
-fluvoxamine
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-medicines for blood pressure
-medicines for seizures
-medicines that relax muscles for surgery
-other medicines that prolong the QT interval (an abnormal heart rhythm)
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine
-rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse. Do not suddenly stop taking this medicine. You may develop a severe reaction. Your health care provider will tell you how much medicine to take. If your health care provider wants you to stop the medicine, the dose may be slowly lowered over time to avoid any side effects.
Do not take this medicine with narcotics. This can cause severe problems including death. Also, you may be more sensitive to lower doses of narcotics after you stop taking this medicine.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care provider if the problem does not go away or is severe.
This medicine can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.
This medicine may increase blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.
If you smoke, tell your doctor if you notice this medicine is not working well for you. Talk to your doctor if you are a smoker or if you decide to stop smoking.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-confusion
-fast, irregular heartbeat
-fever or chills, sore throat
-high blood sugar (increased hunger, thirst or urination; unusually weak or tired, blurry vision)
-inability to keep still
-loss of balance or coordination
-low blood pressure (dizziness; feeling faint or lightheaded, falls; unusually weak or tired)
-males: prolonged or painful erection
-neuroleptic malignant syndrome (confusion; fast, irregular heartbeat; high fever; increased sweating; uncontrollable head, mouth, neck, arm, or leg movements; stiff muscles)
-rash, fever, and swollen lymph nodes
-redness, blistering, peeling or loosening of the skin, including inside the mouth
-seizures
-stroke (changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of balance or coordination)
-suicidal thoughts or other mood changes
-trouble breathing
-trouble swallowing
-uncontrollable head, mouth, neck, arm, or leg movements
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-change in sex drive or performance
-constipation
-drowsiness
-dry mouth
-headache
-tremors
-weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Protect from moisture. Keep the container tightly closed. Do not throw out the packet in the container. It keeps the medicine dry. Get rid of any unused medicine after the expiration date.
-To get rid of medicines that are no longer needed or have expired: Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.