VOCLOSPORIN (vok loe SPOR in) is used to treat active lupus nephritis (lupus-related kidney inflammation). This drug is used with standard therapy for this condition. It is not a cure.

LUPKYNIS Lifestyle Interactions

  • Voclosporin 7.9mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Severe
    • Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Voclosporin together. Taking these together may increase the risk of serious side effects.
    • Notes for Professionals: Advise patients that the use of voclosporin and grapefruit juice is contraindicated; concomitant use may increase the exposure of voclosporin and the risk of voclosporin-related adverse effects such as nephrotoxicity, hypertension, and QT prolongation. Voclosporin is a sensitive CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased voclosporin exposure by approximately 19-fold.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.