PONATINIB (poe NA ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cell from growing. It is used to treat chronic myelogenous leukemia and certain types of acute lymphoblastic leukemia.

ICLUSIG Lifestyle Interactions

  • Ponatinib 15mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Avoid Grapefruit or Grapefruit Juice while taking Ponatinib. Side effects from Ponatinib may get worse. Notify your health care provider if you experience fluid retention, bleeding, rash, high blood pressure, or any other new or unusual side effects.
    • Notes for Professionals: Instruct patients to avoid grapefruit or grapefruit juice with ponatinib due to the potential for increased ponatinib exposure and subsequent toxicity. Ponatinib is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased the ponatinib AUC by 78%.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.