HALOPERIDOL DECANOATE (Generic for HALDOL DECANOATE 100)

Haloperidol Decanoate 100mg/1mL, Suspension for injection

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoking may reduce the effectiveness of this drug in treating your condition; Tobacco smoke contains substances that speed the removal of this drug from the body. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may feel more drowsy or tired, or may experience confusion, dizziness, difficulty in movement or other side effects. If you will stop smoking, use care in driving or operating machinery until you know how this drug will affect you. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking. Report any unusual side effects promptly.

· Notes for Professionals: Tobacco smoke may accelerate the metabolism of haloperidol. Sudden cessation of tobacco smoking may result in a reduced clearance of this antipsychotic, despite the initiation of a nicotine replacement product. Monitor patients carefully when changes in smoking status occur.

Haloperidol Decanoate 100mg/1mL, Suspension for injection

Marijuana

· Severity: Major

· Notes for Consumers: Avoid combining Haloperidol and marijuana. This combination may cause your condition to get worse. Marijuana may also decrease the efficacy of Haloperidol, making it not work as well for you. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice unusual changes in moods or behaviors of any type.

· Notes for Professionals: Haloperidol is sometimes used to treat emesis due to cannabis use; in this case, interactions are not expected; however, patients should be warned about sedation and other potential effects. Patients on chronic haloperidol therapy for psychiatric disorders should avoid use of marijuana. It is recommended that patients avoid the use of marijuana, by any route, if they are treated for a psychiatric history, including psychosis and bipolar disorder, as the cannabinoids (the psychoactive ingredients, such as THC) in marijuana can produce psychotoxic effects and may exacerbate psychiatric disorders. A high frequency of use and use of products with high-potency of THC are potential risk factors for psychiatric effects. Additionally, additive CNS effects, such as sedation or CNS depression are possible. Clinical studies suggest that cannabis use may reduce the efficacy of some antipsychotic drugs. In addition, several cannabinoids in marijuana appear to influence the activity of CYP enzymes and P-glycoprotein, which may alter the concentrations of antipsychotics and influence either safety or efficacy.

Haloperidol Decanoate 100mg/1mL, Suspension for injection

Alcohol

· Severity: Major

· Notes for Consumers: It is recommended that you avoid Alcoholic drinks while you are taking this medication. Alcohol can increase the risk of side effects, such as drowsiness, dizziness, low blood pressure and falls. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: In general, patients should avoid alcohol during haloperidol treatment. Haloperidol may impair alertness, mental and/or physical abilities, and cause hypotension. These effects may be potentiated by alcohol. Patients should be warned of the risks of sedation and hypotension and advised of associated precautions.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>