• No image available for this medication

    • FOSPHENYTOIN SODIUM (Generic for CEREBYX)

    • QTY 150
    • 500 PE/10
    • VIAL

FOSPHENYTOIN (fos FEN i toyn) prevents and controls seizures in people with epilepsy. It may also be used to prevent and treat seizures during or after brain surgery. It works by calming overactive nerves in your body.

FOSPHENYTOIN SODIUM (Generic for CEREBYX) Lifestyle Interactions

  • Fosphenytoin Sodium 75mg/1mL, Solution for injection

    • Interaction: Alcohol
    • Severity: Major
    • Notes for Consumers: You should avoid alcoholic beverages while taking Phenytoin. Alcohol can affect seizure control and interfere with the drug treatment, and may increase the risk of serious side effects. Decreased alertness, drowsiness, falls, or other side effects may occur. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
    • Notes for Professionals: Phenytoin theoretically can add to the CNS-depressant effects of ethanol. Chronic ingestion of ethanol induces hepatic microsomal isozymes and increases the clearance of phenytoin. Ethanol also exhibits epileptogenic potential. Ethanol should generally be avoided in patients on fosphenytoin or phenytoin. Acute ingestion of small amounts of ethanol in non-alcoholic patients does not appear to affect the hepatic metabolism of phenytoin to a clinically significant degree.

  • Fosphenytoin Sodium 75mg/1mL, Solution for injection

    • Interaction: Marijuana
    • Severity: Moderate
    • Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.
    • Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with phenytoin or fosphenytoin. Phenytoin is an inhibitor of CYP2C9 and an inducer of CYP3A4, two isoenzymes responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with phenytoin, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be altered. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

  • Fosphenytoin Sodium 75mg/1mL, Solution for injection

    • Interaction: Caffeine-containing Foods/Beverages
    • Severity: Moderate
    • Notes for Consumers: Hydantoins may decrease the actions of Caffeine; if you have a high intake of caffeinated foods or beverages you may experience a headache or irritability from decreased caffeine levels while taking these drugs until your body adjusts. If you take Caffeine for other purposes, notify your health care provider if you think Caffeine is not working as well for you.
    • Notes for Professionals: Higher caffeine doses may be needed after hydantoin administration; hydantoins increase caffeine elimination.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.