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EPLERENONE (e PLER en one) is a diuretic. It helps you make more urine and to lose salt and excess water from your body. It treats high blood pressure and heart failure. It can treat heart damage after a heart attack.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this drug by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.
Do not take this drug with grapefruit juice.
Talk to your pediatrician regarding the use of this drug in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medicine with any of the following medications:
-boceprevir
-ceritinib
-certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, and telithromycin
-certain diuretics like amiloride, spironolactone, and triamterene
-certain medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
-certain medicines for HIV or AIDS like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir boosted with ritonavir, and tipranavir
-grapefruit and grapefruit juice
-ibritumomab tiuxetan
-idelalisib
-lonafarnib
-mifepristone
-nefazodone
-potassium salts or supplements
-ribociclib
-tucatinib
This medicine may also interact with the following medications:
-certain medicines for high blood pressure like enalapril, candesartan, lisinopril, and valsartan
-erythromycin
-fluconazole
-lithium
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-verapamil
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your doctor or health care provider for regular checks on your progress. Check your blood pressure as directed. Ask your health care provider what your blood pressure should be. Also, find out when you should contact him or her.
Do not treat yourself for coughs, colds, or pain while you are using this medicine without asking your health care provider for advice. Some medicines may increase your blood pressure.
Check with your health care provider if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medicine.
You may need to be on a special diet while taking this medicine. Ask your health care provider. Also, find out how many glasses of fluid you need to drink each day.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medicine. Avoid alcoholic drinks.
Avoid salt substitutes unless you are told otherwise by your health care provider.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your health care provider as soon as possible:
-allergic reactions (skin rash, itching or hives, swelling of the face, lips, or tongue)
-breast enlargement in both males and females
-changes in menstrual cycle
-high potassium levels (chest pain; fast, irregular heartbeat; muscle weakness)
-low blood pressure (dizziness; feeling faint or lightheaded, falls; unusually weak or tired)
Side effects that usually do not require medical attention (report to your health care provider if they continue or are bothersome):
-changes in sex drive or performance
-cough
-diarrhea
-fatigue
-headache
-stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature at 25 degrees C (77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:
-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put into the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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