• Image of Dymista medication

    • DYMISTA (Brand for AZELASTINE-FLUTICASONE)

    • QTY 23
    • 137-50 MCG
    • SPRAY/PUMP

AZELASTINE; FLUTICASONE (a ZEL as teen; floo TIK a sone) is a combination of a histamine blocker and a corticosteroid. This medicine is used to treat the symptoms of allergies like sneezing, itching, and runny or stuffy nose.

DYMISTA (Brand for AZELASTINE-FLUTICASONE) Lifestyle Interactions

  • Azelastine Hydrochloride 137mcg/1actuation, Fluticasone Propionate 50mcg/1actuation, Nasal spray, suspension

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not eat grapefruit or drink grapefruit juice while taking Fluticasone without talking to your doctor or healthcare professional. Side effects from Fluticasone may get worse. Call your doctor or healthcare professional as soon as possible if you have side effects like roundness of the face, high blood pressure, extreme irritability, fainting, stomach pain, or water retention.
    • Notes for Professionals: Instruct patients using inhaled fluticasone propionate products to avoid grapefruit juice. Patients using fluticasone furoate products should be aware of the potential for increased adverse effects if they regularly consume grapefruit juice. Increased systemic corticosteroid effects, including Cushing's syndrome and adrenal suppression, may occur. Fluticasone is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. In drug interaction studies, coadministration with strong inhibitors increased plasma fluticasone propionate exposure resulting in 45% to 86% decreases in serum cortisol AUC. A strong inhibitor increased fluticasone furoate exposure by 1.33-fold with a 27% reduction in weighted mean serum cortisol; this change does not necessitate dose adjustment of fluticasone furoate.

  • Azelastine Hydrochloride 137mcg/1actuation, Fluticasone Propionate 50mcg/1actuation, Nasal spray, suspension

    • Interaction: Alcohol
    • Severity: Moderate
    • Notes for Consumers: Limit alcohol consumption while you are taking this medicine. You may feel drowsy or more tired if you consume alcohol-containing drinks or medications while taking this medicine. Do not drive or operate machinery until you know how this combination affects you. Dizziness, drowsiness, and trouble concentrating may occur.
    • Notes for Professionals: Limit the concurrent use of azelastine and alcohol, as an enhanced CNS depressant effect may occur.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.