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    • CRESEMBA

    • QTY 60
    • 186 MG
    • Capsule

ISAVUCONAZONIUM (I sa vue KON a ZOE NE um) is an antifungal medicine. It is used to treat certain kinds of fungal infections.

CRESEMBA Lifestyle Interactions

  • Isavuconazonium sulfate 186mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Severe
    • Notes for Consumers: Do not take grapefruit juice with Isavuconazonium. Discuss possible alternative treatment options with your prescriber. Taking grapefruit juice together with your medicine may increase the risk for adverse effects on the liver. Discuss any new or worsening side effects with your health care provider such as dark yellow or brown urine, general ill feeling or flu-like symptoms, light-colored stools, loss of appetite, nausea, right upper belly pain, unusually weak or tired, yellowing of the eyes or skin.
    • Notes for Professionals: Concomitant use of isavuconazonium with grapefruit juice is contraindicated due to the risk for increased isavuconazole serum concentrations and serious adverse reactions, such as hepatic toxicity. Isavuconazole, the active moiety of isavuconazonium, is a sensitive substrate of hepatic isoenzyme CYP3A4; grapefruit juice is a strong inhibitor of this enzyme. According to the manufacturer, coadministration of isavuconazole with strong CYP3A4 inhibitors is contraindicated. Isavuconazole serum concentrations were increased 5-fold when coadministered with ketoconazole, another strong CYP3A4 inhibitor.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.