CINACALCET HCL (Generic for SENSIPAR)

Cinacalcet Hydrochloride 30mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Cinacalcet with grapefruit juice. Grapefruit juice and grapefruit-containing foods may increase the effects of Cinacalcet. Contact your prescriber immediately if you experience burning, numbness, pricking, tickling or tingling of the face, lips, tongue, hands or feet, muscle aches or pains, muscle cramps of the back and legs, difficulty swallowing, irritability, confusion, hallucinations or convulsions or seizures while taking Cinacalcet.

· Notes for Professionals: Grapefruit juice contains a compound that inhibits the CYP3A4 isozyme in the gut wall. Co-administration can potentially decrease hepatic metabolism and increase the serum concentration of cinacalcet. Since the extent to which this interaction occurs is not known, patients should be counseled to avoid grapefruit juice while taking cinacalcet.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>