ENCORAFENIB (en koe raf e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat melanoma and colorectal cancer.

BRAFTOVI Lifestyle Interactions

  • Encorafenib 75mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take Encorafenib and Grapefruit juice together. Side effects from Encorafenib may be increased if you take Grapefruit Juice or grapefruit-containing foods.
    • Notes for Professionals: Advise patients to avoid grapefruit juice while taking encorafenib due to increased encorafenib exposure. Encorafenib is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration of a strong CYP3A4 inhibitor with a single 50 mg dose of encorafenib (0.1 times the recommended dose) increased the encorafenib AUC and Cmax by 3-fold and 68%, respectively.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.