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OLANZAPINE (oh LAN za peen) is used to treat schizophrenia.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

This medicine is for injection into a muscle by a health care professional. It will be given at regular intervals. Do not stop taking except on the advice of your doctor or health care professional.
A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

Do not take this medicine with any of the following medications:
-dronedarone
-cisapride
-metoclopramide
-pimozide
-thioridazine
This medicine may also interact with the following medications:
-alcohol
-antihistamines for allergy, cough, and cold
-atropine
-carbamazepine
-certain medicines for anxiety or sleep
-certain medicines for bladder problems like oxybutynin, tolterodine
-certain medicines for depression like amitriptyline, fluoxetine, sertraline
-certain medicines for stomach problems like dicyclomine, hyoscyamine
-certain medicines for travel sickness like scopolamine
-fluvoxamine
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-levodopa or other medicines for Parkinson's disease
-medicines for blood pressure
-medicines for seizures
-medicines that relax muscles for surgery
-narcotic medicines for pain
-omeprazole
-other medicines that prolong the QT interval (an abnormal heart rhythm)
-phenothiazines like chlorpromazine, prochlorperazine
-rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Your condition will be monitored carefully while you are receiving this medicine. Tell your health care professional if your symptoms do not start to get better or if they get worse.
After your injection, you will need to stay at the clinic where you receive the injection for at least 3 hours so the doctor can make sure you do not have symptoms of Post-injection Delirium Sedation Syndrome (PDSS). PDSS is a serious problem that can happen if the medicine gets into your blood too fast. Some symptoms of PDSS include drowsiness, dizziness, feeling confused, having trouble talking or walking, seizures, having stiff or shaking muscles, feeling weak, being anxious or angry, passing out or fainting, and having blood pressure changes. When you leave the clinic, someone must be with you. If you have symptoms of PDSS after you leave the clinic or hospital, get medical help right away.
Do not drive or use heavy machinery for the rest of the day after receiving your injection. You may get dizzy or drowsy. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
This medicine may increase blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.
This drug can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.
If you smoke, tell your doctor if you notice this medicine is not working well for you. Talk to your doctor if you are a smoker or if you decide to stop smoking.

Contact your health care provider as soon as possible if you miss an appointment for your injection.

Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast enlargement in both males and females
-breathing problems
-confusion
-fast, irregular heartbeat
-fever or chills, sore throat
-inability to keep still
-males: prolonged or painful erection
-missed menstrual periods
-pain, redness or irritation at site where injected
-problems with balance, talking, walking
-rash, fever, and swollen lymph nodes
-redness, blistering, peeling or loosening of the skin, including inside the mouth
-seizures
-signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision
-signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
-signs and symptoms of neuroleptic malignant syndrome like confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles
-sudden numbness or weakness of the face, arm, or leg
-suicidal thoughts or other mood changes
-trouble swallowing
-uncontrollable movements of the arms, face, head, mouth, neck, or upper body
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-change in sex drive or performance
-constipation
-drowsiness
-weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.