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    • CLINDAMYCIN PHOS-TRETINOIN (Generic for ZIANA)

CLINDAMYCIN; TRETINOIN (KLIN da MYE sin; TRET i noe in) is a combination of a topical antibiotic and a form of vitamin A. It is used to treat acne.

CLINDAMYCIN PHOS-TRETINOIN (Generic for ZIANA) Lifestyle Interactions

  • Almotriptan Malate 12.5mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Avoid grapefruit juice while taking Almotriptan. Side effects from Almotriptan may get worse if you take these agents together. Taking these drugs together could result in serious side effects such as chest pain, chest tightness or pressure, confusion, dizziness, drowsiness, excessive dry mouth, excessive nausea/vomiting, fever, loss of coordination, muscle twitching or weakness, sweating, tremor, and/or palpitations. Report any of these effects immediately should they occur.
    • Notes for Professionals: Avoid grapefruit and grapefruit juice while taking almotriptan, as coadministration may increase the systemic exposure of almotriptan. If coadministered, the recommended starting dose of almotriptan is 6.25 mg; do not exceed 12.5 mg within a 24-hour period. Avoid coadministration in patients with renal or hepatic impairment. Almotriptan is a CYP3A4 substrate and grapefruit is a potent CYP3A4 inhibitor. In a drug interaction study, coadministration of almotriptan and ketoconazole, another potent CYP3A4 inhibitor, resulted in an approximately 60% increase in almotriptan exposure.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.