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ZEPATIER Lifestyle Interactions
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Elbasvir 50mg, Grazoprevir 100mg, Oral tablet
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not take these drugs together without talking to your health care provider. Taking these drugs together may increase your risk for side effects, including liver toxicity. Discuss any new or worsening side effects with your health care provider.• Notes for Professionals: Concurrent administration of elbasvir with grapefruit juice should be avoided if possible. Giving elbasvir with grapefruit juice is expected to significantly increase the plasma concentrations of elbasvir, and may result in adverse effects (i.e., elevated ALT concentrations and hepatotoxicity). Grapefruit is a strong inhibitor of the hepatic enzyme CYP3A, while elbasvir is metabolized by CYP3A. 
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.