ZAFIRLUKAST (Generic for ACCOLATE)

Zafirlukast 20mg, Oral tablet

Food

· Severity: Major

· Notes for Consumers: Food will decrease the amount of Zafirlukast your body can absorb. Therefore, take Zafirlukast on an empty stomach at least 1 hour before or 2 hours after meals.

· Notes for Professionals: Because the bioavailability of zafirlukast is substantially decreased when taken with food, take zafirlukast on an empty stomach at least 1 hour before or 2 hours after meals.

Zafirlukast 20mg, Oral tablet

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with zafirlukast. Zafirlukast is an inhibitor of CYP2C9 and CYP3A4, two isoenzymes responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with zafirlukast the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be reduced. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>