• Image of Xifaxan medication

    • XIFAXAN

    • QTY 42
    • 550 MG
    • Tablet

RIFAXIMIN (ri FAX i men) is an antibiotic. It is used to treat traveler's diarrhea and irritable bowel syndrome with diarrhea. It is also used to prevent hepatic encephalopathy, a brain disorder that can occur due to severe liver disease.

XIFAXAN Lifestyle Interactions

  • Rifaximin 550mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Moderate
    • Notes for Consumers: Taking rifaximin with grapefruit juice may increase the amount of rifaximin in your body. Discuss any new or worsening side effects with your health care provider.
    • Notes for Professionals: Although the clinical significance of this interaction is unknown, concurrent use of rifaximin, a P-glycoprotein (P-gp) substrate, and grapefruit juice, a P-gp inhibitor, may substantially increase the systemic exposure to rifaximin; caution is advised if these drugs must be administered together. During one in vitro study, coadministration with cyclosporine, a potent P-gp inhibitor, resulted in an 83-fold and 124-fold increase in the mean Cmax and AUC of rifaximin, respectively. In patients with hepatic impairment, the effects of reduced metabolism and P-gp inhibition may further increase exposure to rifaximin.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.