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COLLAGENASE (kohl LAH jen ace) is used to treat Dupuytren's contracture. This medicine may help straighten a bent finger by breaking up hard tissue. It is also used for Peyronie's disease by breaking up the hard tissue plaque that causes the curvature in the penis.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medicine is for injection into the hand or penis. It is given by a health care professional in a hospital or clinic setting.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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-aspirin and aspirin-like medicines
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medicine.
If being treated for Dupuytren's contracture, return to your healthcare provider the day after your hand is injected. In the meantime, do not flex or extend the fingers of your hand that was injected. Do not touch your finger that was injected, and elevate your hand until bedtime. Do not perform activity with the injected hand until you are told that it is OK. Follow any instructions about wearing a splint or performing finger exercises. Also, call your healthcare provider if you get increasing redness or swelling in the hand, if you have numbness or tingling in the treated finger, or if you have trouble bending the finger after the swelling goes down.
If being treated for Peyronie's disease, you will need to return to your healthcare provider for a manual procedure that will stretch and help straighten your penis. Also, your healthcare provider will show you how to gently stretch your penis at home. Do not resume sexual activity until you are told that it is okay. Follow instructions on when to return for follow-up visits. Immediately call your doctor if you have trouble stretching or straightening your penis, or if you have pain or other concerns.
Immediately call your healthcare provider if you get a fever or chills.
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It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-chest pain or palpitations
-infection (fever, chills, increasing redness or swelling at treated site)
-numbness or tingling in a treated hand
-popping sound or sensation in an erect penis
-sudden back pain or trouble walking
-sudden loss of the ability to maintain an erection
-trouble breathing
-trouble urinating or blood in the urine
-unusual pain, swelling, or bruising of the penis
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-bleeding or bruising at site where injected
-irritation at site where injected
-mild pain or swelling at site where injected
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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