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    • XENLETA

    • QTY 10
    • 600 MG
    • Tablet

LEFAMULIN (lef a MUE lin) is a pleuromutilin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

XENLETA Lifestyle Interactions

  • Lefamulin 600mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods together with Lefamulin without talking with your health care provider. Side effects of Lefamulin may get worse. Tell your health care provider immediately if you notice any new or unusual side effects including diarrhea, nausea, vomiting, and trouble sleeping.
    • Notes for Professionals: Advise patients to avoid grapefruit juice or grapefruit-containing foods while taking oral lefamulin due to increased lefamulin exposure; grapefruit juice may be administered with intravenous lefamulin. Lefamulin is a CYP3A4 and P-gp substrate; grapefruit juice is a P-gp and strong CYP3A4 inhibitor. Coadministration of a combined P-gp and strong CYP3A4 inhibitor increased the exposure of oral and intravenous lefamulin by 165% and 31%, respectively.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.