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TURALIO Lifestyle Interactions
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Pexidartinib 200mg, Oral capsule
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not take Pexidartinib and Grapefruit Juice together without talking to your doctor or healthcare professional. Side effects from Pexidartinib may get worse if you take Grapefruit Juice or grapefruit-containing foods. Contact your doctor or healthcare professional if you experience new or worsening side effects including signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin.• Notes for Professionals: Advise patients to avoid coadministration of pexidartinib with grapefruit juice as concurrent use may increase pexidartinib exposure. Pexidartinib is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration of another strong CYP3A4 inhibitor increased pexidartinib exposure by 70%.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.