ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

TOLSURA Lifestyle Interactions

  • Itraconazole 65mg, Oral capsule

    • Interaction: Marijuana
    • Severity: Moderate
    • Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.
    • Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with itraconazole. Itraconazole is an inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with itraconazole, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be reduced. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

  • Itraconazole 65mg, Oral capsule

    • Interaction: Food
    • Severity: Moderate
    • Notes for Consumers: Itraconazole oral solution should be taken without food, while Itraconazole capsules should be taken with a full meal.
    • Notes for Professionals: Oral bioavailability of itraconazole from the capsules is increased if administered with a meal or cola beverage. Administration with orange juice should be avoided.

  • Itraconazole 65mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Mild
    • Notes for Consumers: It is best not to change your usual intake of grapefruit juice while taking Itraconazole. Grapefruit juice may decrease the actions of Itraconazole.
    • Notes for Professionals: Grapefruit juice reduced the mean peak itraconazole concentration by 35 percent when itraconazole capsules were administered with grapefruit juice in healthy volunteers; the AUC was reduced by an average of 43 percent compared to administration with water. Conversely, another study reported that grapefruit juice did not significantly affect the bioavailability of itraconazole capsules.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.