• Image of TIBSOVO medication

    • TIBSOVO

    • QTY 60
    • 250 MG
    • Tablet

IVOSIDENIB (EYE voe SID e nib) targets proteins in cancer cells and stops the cancer cells from growing. It treats acute myelogenous leukemia and cholangiocarcinoma.

TIBSOVO Lifestyle Interactions

  • Ivosidenib 250mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not ingest Grapefruit or Grapefruit Juice while on Ivosidenib therapy. Side effects from Ivosidenib may get worse if you take Grapefruit Juice or grapefruit-containing foods. Contact your prescriber immediately if you experience chest pain, dizziness, fainting or falling spells, palpitations, shortness of breath, or a change in your heartbeat (such as a fast or irregular heartbeat).
    • Notes for Professionals: Advise patients to avoid grapefruit juice while taking ivosidenib due to increased plasma concentrations of ivosidenib, which increases the risk of QT prolongation or other toxicities. Ivosidenib is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased ivosidenib single-dose AUC to 269% of control, with no change in Cmax.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.