SYMPROIC

Naldemedine 0.2mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take these drugs together without talking to your health care professional. Side effects from Naldemedine may get worse. Contact your health care provider if you experience severe or worsening stomach pain, diarrhea, nausea and vomiting, or other unusual effects.

· Notes for Professionals: Monitor for potential naldemedine-related adverse reactions if coadministered with grapefruit. The plasma concentrations of naldemedine may be increased during concurrent use. Naldemedine is a substrate of CYP3A4 and P-gp; grapefruit is a moderate P-gp inhibitor and a strong CYP3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>