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    • RIVAROXABAN (Generic for XARELTO)

RIVAROXABAN (ri va ROX a ban) prevents or treats blood clots. It is also used to lower the risk of stroke in people with AFib (atrial fibrillation). It can be used to lower the risk of heart attack or stroke in people with heart or peripheral artery disease. It belongs to a group of medications called blood thinners.

RIVAROXABAN (Generic for XARELTO) Lifestyle Interactions

  • Rivaroxaban 2.5mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Tell your health care professional that you drink Grapefruit Juice before you take Rivaroxaban. If you drink Grapefruit Juice and take Rivaroxaban, your risk of bleeding is increased. Immediately report any unusual bleeding or bruising.
    • Notes for Professionals: Avoid concomitant administration of rivaroxaban and grapefruit juice; significant increases in rivaroxaban exposure may increase bleeding risk. Rivaroxaban is a substrate of CYP3A4/5 and the P-glycoprotein (P-gp) transporter. Grapefruit juice is a combined P-gp inhibitor and strong CYP3A4 inhibitor. Concurrent use of a single dose of rivaroxaban and ritonavir, a combined P-gp and strong CYP3A4 inhibitor, led to an increase in the steady-state rivaroxaban AUC by 150% and to an increase in Cmax by 60%. Similar increases in pharmacodynamic effects such as factor Xa inhibition and PT prolongation were also observed.

  • Rivaroxaban 2.5mg, Oral tablet

    • Interaction: Alcohol
    • Severity: Mild
    • Notes for Consumers: Tell your health care professional if you drink alcohol. If you drink alcohol, rivaroxaban may not work as well for you. Immediately report any pain, swelling, redness, or warmth in a leg or difficulty breathing.
    • Notes for Professionals: Use rivaroxaban cautiously in patients who consume alcohol. Coadministration of rivaroxaban and ethanol may result in decreased rivaroxaban exposure and may decrease the efficacy of rivaroxaban. Ethanol is an inducer of CYP3A4, and rivaroxaban is a substrate of CYP3A4. If a patient taking rivaroxaban also consumes alcohol, monitor the patient for signs of lack of efficacy of rivaroxaban.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.