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PROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. It works by blocking histamine, a substance released by the body during an allergic reaction. It may also help you relax, go to sleep, and relieve nausea, vomiting, or pain before or after procedures. It can also prevent and treat motion sickness. It works by helping your nervous system calm down by blocking substances in the body that may cause nausea and vomiting. It belongs to a group of medications called antihistamines.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.
Talk to your care team about the use of this medication in children. Special care may be needed. This medication should not be given to infants and children younger than 2 years old.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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-Alcohol
-Antihistamines for allergy, cough, and cold
-Atropine
-Certain medications for anxiety or sleep
-Certain medications for bladder problems like oxybutynin, tolterodine
-Certain medications for depression like amitriptyline, fluoxetine, sertraline
-Certain medications for Parkinson's disease like benztropine, trihexyphenidyl
-Certain medications for stomach problems like dicyclomine, hyoscyamine
-Certain medications for travel sickness like scopolamine
-Epinephrine
-General anesthetics like halothane, isoflurane, methoxyflurane, propofol
-Ipratropium
-MAOIs like Marplan, Nardil, and Parnate
-Medications for high blood pressure
-Medications for seizures like phenobarbital, primidone, phenytoin
-Medications that relax muscles for surgery
-Metoclopramide
-Narcotic medications for pain
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if symptoms do not start to get better or if they get worse.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.
This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.
This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.
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If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
-High fever stiff muscles, increased sweating, fast or irregular heartbeat, and confusion, which may be signs of neuroleptic malignant syndrome
-Infection—fever, chills, cough, or sore throat
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Seizures
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
-Trouble passing urine
-Uncontrolled and repetitive body movements, muscle stiffness or spasms, tremors or shaking, loss of balance or coordination, restlessness, shuffling walk, which may be signs of extrapyramidal symptoms (EPS)
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Confusion
-Constipation
-Dizziness
-Drowsiness
-Dry mouth
-Sensitivity to light
-Vivid dreams or nightmares
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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