PROMACTA

Eltrombopag Olamine 75mg, Oral tablet

food high in calcium

· Severity: Major

· Notes for Consumers: Take Eltrombopag 1 hour before or 4 hours after you have food. Foods high in calcium may decrease the amount of Eltrombopag absorbed by the stomach, which can decrease the effects of Eltrombopag.

· Notes for Professionals: Eltrombopag chelates polyvalent cations (e.g., calcium, aluminum, and magnesium) in food. Systemic exposure to eltrombopag may be decreased when it is coadministered with a polyvalent cation-containing product. Eltrombopag should not be taken within 4 hours of any oral products containing polyvalent cations, such as calcium salts.

Eltrombopag Olamine 75mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco may decrease the actions of Eltrombopag. Although an interaction is possible, these drugs may be used together. Your drug therapy will be closely monitored by your health care provider.

· Notes for Professionals: Eltrombopag is metabolized by CYP1A2. The significance of administering inducers of CYP1A2, such as tobacco, on the systemic exposure of eltrombopag has not been established. Monitor patients for a decrease in the efficacy of eltrombopag if these drugs are coadministered.

Eltrombopag Olamine 75mg, Oral tablet

Foods High in Iron

· Severity: Major

· Notes for Consumers: Take Eltrombopag 1 hour before or 4 hours after you have food. Foods high in iron may decrease the amount of Eltrombopag absorbed by the stomach, which can decrease the effects of Eltrombopag.

· Notes for Professionals: Eltrombopag chelates polyvalent cations (e.g., calcium, aluminum, and magnesium) in food. Systemic exposure to eltrombopag may be decreased when it is coadministered with a polyvalent cation-containing product. Eltrombopag should not be taken within 4 hours of any oral products containing polyvalent cations, such as aluminum salts, (like aluminum hydroxide), calcium salts, (including calcium carbonate), and magnesium salts.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>