POMALIDOMIDE (pom a LID oh mide) is a chemotherapy drug used to treat multiple myeloma and Kaposi sarcoma. It targets specific proteins within cancer cells and stops the cancer cell from growing.

POMALYST Lifestyle Interactions

  • Pomalidomide 2mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take grapefruit juice without talking to your health care professional. Avoid grapefruit juice during pomalidomide treatment if possible. Taking pomalidomide with grapefruit juice may increase the levels of pomalidomide in your body, especially if you are taking certain other medicines. This may increase the risk for side effects such as low blood cell counts, increased risk of bleeding, fatigue, constipation / diarrhea, and nausea.
    • Notes for Professionals: Pomalidomide is a substrate of CYP1A2, CYP3A, and P-glycoprotein (P-gp). Grapefruit juice is an inhibitor of P-gp. Avoid concomitant use of pomalidomide and grapefruit juice, particularly in combination with both a strong CYP1A2 and a strong CYP3A4 inhibitor. If coadministration of pomalidomide with grapefruit juice and these CYP inhibitors cannot be avoided, decrease the dose of pomalidomide to 2 mg once daily and monitor for efficacy and toxicity. If pomalidomide is co-administered with grapefruit juice in the absence of both a CYP1A2 and CYP3A4 inhibitor, monitor closely for pomalidomide toxicity.

  • Pomalidomide 2mg, Oral capsule

    • Interaction: Tobacco
    • Severity: Moderate
    • Notes for Consumers: If you smoke cigarettes, talk to your health care professional. Smoking cigarettes while taking pomalidomide may decrease pomalidomide levels, causing therapy to not work as well for you.
    • Notes for Professionals: Cigarette smoking may reduce pomalidomide exposure due to CYP1A2 induction. Patients should be advised that smoking tobacco may reduce the efficacy of pomalidomide.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.