Polivy Food, Alcohol, Supplements and Drug Interactions

POLIVY

QTY 1 • 140 MG • VIAL • Near 77381

POLATUZUMAB VEDOTIN (poe la tooz ue mab ve doe tin) is a monoclonal antibody and a chemotherapy drug. It is used to treat diffuse large B-cell lymphoma.

POLIVY Lifestyle Interactions

Polatuzumab Vedotin 140mg, Powder for solution for injection

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Do not eat or drink Grapefruit or Grapefruit Juice while taking Polatuzumab Vedotin without talking to your health care provider. Grapefruit Juice or grapefruit-containing foods may increase side effects from Polatuzumab Vedotin.

· Notes for Professionals: Advise patients to avoid grapefruit juice while taking polatuzumab vedotin due to the risk of elevated exposure to the cytotoxic component of polatuzumab vedotin, MMAE. MMAE is metabolized by CYP3A4; grapefruit juice is a strong CYP3A4 inhibitor. Strong CYP3A4 inhibitors are predicted to increase the exposure of MMAE by 45%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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