PHASEAL ADAPTER Lifestyle Interactions

  • Crizotinib 250mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Avoid Grapefruit or Grapefruit Juice while taking Crizotinib treatment. Side effects from Crizotinib may get worse if you take grapefruit or grapefruit juice. Contact your health care provider if you experience vision changes, nausea, vomiting, diarrhea, swelling, new or worsening tingling in fingers and/or toes, or inability to pick-up items with your fingers, or other unusual effects.
    • Notes for Professionals: Due to the potential for increased crizotinib exposure and side effects, patients should be advised to avoid intake of grapefruit or grapefruit juice during crizotinib therapy. Crizotinib is a CYP3A substrate and grapefruit juice is a strong CYP3A inhibitor. Coadministration with one strong CYP3A inhibitor increased the AUC and Cmax of single-dose crizotinib by 216% and 44%, respectively. Concomitant use with another strong CYP3A4 inhibitor increased the steady-state AUC and Cmax of crizotinib by 57% and 33%, respectively, compared to crizotinib alone.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.