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    • NICARDIPINE HCL-0.9% NACL (Generic for CARDENE I.V.)

NICARDIPINE (nye KAR de peen) is a calcium channel blocker. It relaxes your blood vessels and decreases the amount of work the heart has to do. It treats high blood pressure.

NICARDIPINE HCL-0.9% NACL (Generic for CARDENE I.V.) Lifestyle Interactions

  • Nicardipine Hydrochloride 0.1mg/1mL, Sodium Chloride 0.9%, Solution for injection

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Avoid taking Nicardipine with grapefruit juice. Grapefruit juice and grapefruit-containing foods may increase the effects of Nicardipine. If the blood pressure drops too low while taking this medicine, you may become dizzy or feel faint; do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away while taking this medicine. If you notice new or increased swelling of your legs or ankles, tell your health care provider.
    • Notes for Professionals: Grapefruit juice contains compounds that inhibit the cytochrome P-450 CYP3A4 isozyme in the gut wall. Grapefruit juice can increase the serum concentrations and oral bioavailability of nicardipine. Co-administration of oral nicardipine with grapefruit juice significantly increases the AUC and peak plasma concentrations of nicardipine; the half-life of nicardipine is not affected. Grapefruit juice does not affect the pharmacokinetics of IV nicardipine. It is generally recommended to avoid grapefruit juice ingestion during nicardipine therapy.

  • Nicardipine Hydrochloride 0.1mg/1mL, Sodium Chloride 0.9%, Solution for injection

    • Interaction: Marijuana
    • Severity: Moderate
    • Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.
    • Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with nicardipine. Nicardipine is an inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with nicardipine, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be reduced. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.