What is the Best Injection for Weight Loss?

With obesity affecting millions of Americans and traditional methods not always providing adequate results, injectable weight loss treatments offer new hope. You may find yourself asking what is the best injection for weight loss? Whether you've heard different weight loss shots names in the news or you're searching for which weight loss injection is best, this guide will help you understand your options for medical weight loss injections.

 

What is the best injection for weight loss?

If you're researching diet shots for weight loss and shots that help you lose weight, it's important to understand that that there are several injectable weight loss medications available that represent a significant advancement in obesity treatment. Choosing which one is right for you depends on several factors, including your individual health needs, lifestyle, and medical history.

 

When can injectable weight loss medication be used?

Before considering injectable weight loss medications, it's important to know who can benefit from them. Injectables for weight loss are prescribed under specific circumstances to ensure safety and effectiveness. These treatments are designed for individuals who meet specific health criteria and are ready to make lifestyle changes.

Who is eligible?

Before considering getting a shot to make you lose weight, you need to meet specific criteria:

• BMI (Body mass index) of 30 or higher: This indicates obesity, which is a primary factor for eligibility.
• BMI of 27 or higher with weight-related health conditions: If your BMI falls into this range, you may be eligible if you have specific health issues such as:
• Type 2 diabetes
• High blood pressure
• High cholesterol
• Sleep apnea
• Heart disease
• Joint problems
• Fatty liver disease

Before prescribing these medications, healthcare providers will also consider if you:

• Have tried previous weight loss attempts through lifestyle changes without much success
• Are committed to maintaining a balanced diet and regular exercise
• Are comfortable giving yourself injections or having someone available who can

Your provider will review your medical history to determine which is the best weight loss injection for you. They will also provide regular medical supervision to monitor progress and manage any side effects that might occur.

 

How do weight loss injection medications work?

When considering weight loss medicine injection options, it's important to understand their mechanism of action. These medications work by mimicking two natural gut hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). GLP-1 helps regulate appetite and digestion, signaling the brain when you're full. GIP plays a role in managing blood sugar levels after meals. These hormones are key to regulating appetite, digestion, and metabolism. Appetite control:

• Reduces hunger signals
• Increases feeling of fullness
• Decreases food cravings
• May shift food preferences away from high-calorie options

Digestive changes:

• Slows stomach emptying
• Extends feeling of fullness
• Regulates blood sugar levels
• Improves insulin sensitivity

Metabolic impact:

• Enhances fat burning
• Reduces fat storage
• Improves energy utilization
• Balances metabolic hormones

 

Best weight loss injections in 2024

For those researching weight reduction injection options or looking for the best weight loss injections, there are several highly effective options available. To help you figure out which slimming injections you should choose, here's a detailed look at the top choices:

Tirzepatide (Zepbound/Mounjaro)

Tirzepatide, marketed under Mounjaro and Zepbound, is a dual-action medication. It targets both GLP-1 and GIP receptors and regulates appetite and insulin secretion. Key features:

• Mechanism: By activating both GLP-1 and GIP receptors, tirzepatide improves insulin sensitivity while reducing appetite. This dual action helps regulate blood sugar levels and promotes feelings of fullness.
• Administration: It is administered as a once-weekly injection.
• Average weight loss: Users can expect an average weight loss between 15% and 21% of their body weight over approximately 72 weeks.
• Available strengths: Available in multiple strengths, including 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg.

Pros:

• Has shown the highest average weight loss among available options
• Improves blood sugar control for those with type 2 diabetes
• May help reduce cardiovascular risk factors
• Offers once-weekly dosing

Cons:

• Can be more expensive than other options
• May require insurance prior authorization before starting treatment
• May have supply limitations due to high demand

Semaglutide (Wegovy/Ozempic)

Semaglutide is available under the brand names Wegovy and Ozempic. Wegovy is specifically approved for chronic weight management, while Ozempic is primarily used to treat type 2 diabetes but may also be prescribed off-label for weight loss. Key Features:

• Mechanism: As a GLP-1 receptor agonist, semaglutide slows gastric emptying and increases feelings of fullness by acting on appetite-regulating centers in the brain.
• Administration: It is given as a once-weekly injection.
• Average weight loss: Users can expect to lose up to 15% of their body weight over about 68 weeks.
• Available strengths: The dosing typically ranges from 0.25 mg to 2.4 mg.

Pros:

• Proven track record of effectiveness and safety
• Tolerated well with manageable side effects
• Has established insurance coverage in many cases

Cons:

• A gradual dose increase is necessary to minimize gastrointestinal side effects such as nausea and diarrhea.
• Regular monitoring by healthcare providers is essential to follow progress and adjust dosages as needed.

Liraglutide (Saxenda)

Liraglutide, marketed as Saxenda for weight management, was one of the first GLP-1 receptor agonists approved for this purpose. Because it's been used for a long time and has a good safety record, it's a common choice for many people. Key features:

• Mechanism: Like semaglutide, liraglutide mimics GLP-1 to make you feel full and slow down the emptying of your stomach.
• Administration: This medication requires daily injections.
• Average weight loss: Users can expect an average weight loss of around 8% of their body weight over approximately 56 weeks.
• Maximum dose: The maximum recommended dose is 3 mg daily.

Pros:

• A long history of use and a well-established safety profile
• Flexible dosing options that allow healthcare providers to tailor treatment based on each patient's needs
• Wide availability

Cons:

• The requirement for daily injections may be less convenient compared to weekly options.
• Average weight loss tends to be lower than that seen with newer medications.

 

Most popular weight loss injections

You may ask yourself what shot helps you lose weight or which weight loss injection works best? Here's a comprehensive overview of the top weight loss injections available today:

Drug Name	Drug Class	Common Dosage (Adults)	Average Weight Loss	WellRx Savings Card
Zepbound	GLP-1/GIP agonist	2.5-15 mg weekly	15-21%	Link Out
Wegovy	GLP-1 agonist	0.25-2.4 mg weekly	15%	Link Out
Mounjaro	GLP-1/GIP agonist	2.5-15 mg weekly	15-21%	Link Out
Saxenda	GLP-1 agonist	0.6-3 mg daily	8%	Link Out
Ozempic	GLP-1 agonist	0.25-2 mg weekly	9-12%	Link Out

How often and for how long can you take injectable weight loss drugs?

Understanding the frequency and duration of injectable weight loss medications is essential for achieving your goals. This consideration is crucial when exploring different weight loss injections and determining which option is best for you.

Administration schedules

Weight loss injections are usually given on specific schedules. Weekly injections, such as Zepbound, Wegovy, Mounjaro, and Ozempic, are administered once a week. Daily injections, like Saxenda, are given every day.

Treatment duration

Treatment generally consists of two phases. The initial phase lasts 3 to 6 months. During this time, your healthcare provider will check to see if the medication is effective. If you continue seeing positive results without many side effects, you may enter the maintenance phase. This allows you to stay on the medication as long as approved by your provider.

What are the strongest prescription weight loss injections?

Several factors determine the most effective injection for losing weight. Here's an overview of the top weight loss injections on the market:

Drug Name	Weight Loss Potential	Mechanism	Effectiveness Rating
Tirzepatide (Zepbound/Mounjaro)	Up to 21% body weight loss	Dual hormone action targeting GLP-1 and GIP receptors to regulate appetite and insulin levels.	Highest effectiveness rating among options available today.
Semaglutide (Ozempic/Wegovy)	Up to 15% body weight loss	GLP-1 receptor agonist that controls appetite and slows gastric emptying.	Strong clinical data supports its effectiveness for weight management.
Liraglutide (Saxenda)	Up to 8% body weight loss	Mimics GLP-1 to enhance fullness and slow gastric emptying.	Moderately effective compared to newer options.

Choosing the best weight loss shot: Factors your healthcare provider will consider

Selecting the right injection requires careful consideration. Before beginning any treatment, it's essential to research and determine what is the best weight loss shot for your individual needs. Here's what your healthcare provider will evaluate to help identify the most effective weight loss injection for you.

Medical history

Your medical history plays an important role in determining suitable medications:

• Current health conditions
• Previous attempts at losing weight
• Family health history
• Medication interactions
• Allergies and sensitivities

Body Mass Index (BMI)

Your BMI helps determine which weight-loss treatments might be right for you. It also helps set realistic weight loss goals. Knowing how your weight has changed over time and understanding your body composition can help your doctor create a personalized treatment plan. Even how your weight is distributed can affect your health.

Lifestyle factors

Lifestyle factors, such as daily routines, exercise habits, dietary preferences, stress management, sleep patterns, work schedules, and social support, play a big role in determining the best treatment for you.

Cost and coverage

The cost of treatment is also important. Insurance coverage can vary, and out-of-pocket expenses may apply. To help reduce costs, manufacturer savings programs and discounts are available through ScriptSave® WellRx. It's important to consider whether you will be able to afford your medications for as long as needed.

Alternatives to injection weight loss medication and other weight loss treatments

While injectable medications prove highly effective options available today, other alternatives exist that may be right for you, depending upon your specific circumstances.

Oral medications

Oral alternatives may be appealing to some people. Prescription pills are designed to help you manage your weight by targeting appetite suppression or increasing metabolism. Also, FDA-approved over-the-counter supplements can aid weight loss, although their effectiveness can vary widely. Common examples of oral medications include:

• Appetite suppressants such as Phentermine suppress appetite by affecting the brain's hunger centers.
• Metabolism boosters, such as Orlistat, prevent the absorption of dietary fat in the intestines.

These medications should be used under a healthcare provider's supervision.

Lifestyle modifications

Maintaining a healthy lifestyle is crucial for weight loss success and preventing you from regaining weight. A balanced diet rich in whole foods, combined with regular exercise, stress management, and adequate sleep, can significantly contribute to weight loss.

Surgical options

For people with severe obesity, surgical procedures like gastric bypass or sleeve gastrectomy may be considered. These procedures can lead to significant weight loss and improve related health conditions.

How to prevent weight gain

Maintaining weight loss requires a combination of healthy eating, physical activity, and behavioral strategies. To maintain weight loss, a balanced approach is key. Healthy eating:

• Choose whole foods like fruits, vegetables, lean proteins, and whole grains.
• Practice portion control and mindful eating.
• Stay hydrated to avoid confusing thirst with hunger.

Regular exercise:

• Aim for at least 150 minutes of moderate-intensity exercise per week.
• Incorporate both cardio and strength training.

Behavioral strategies:

• Manage stress through techniques like meditation or yoga.
• Prioritize quality sleep.
• Surround yourself with a supportive social network.
• Track your progress to stay accountable.

Key takeaways

Injectable medications for weight loss have become increasingly popular and can be an effective option if you are struggling to shed pounds through traditional methods. However, there are many weight loss injections names out there. When considering which weight loss injection is best for you, a healthcare provider can help you find the most suitable option. While the most popular weight loss injections can help you lose weight, they work best when combined with a healthy lifestyle that includes balanced nutrition and regular exercise. Additionally, resources like ScriptSave® WellRx can help you save on prescription costs, making these treatments more accessible.

Get your free WellRX account and start saving on your medications

Don't let the cost of weight loss medications prevent you from achieving your health goals. Sign up for a free ScriptSave® WellRx account today and save up to 80%* on your prescription medications. Our program helps make weight loss injections more affordable and accessible. *DISCOUNT ONLY – NOT INSURANCE. The program is administered by Medical Security Card Company, LLC. Start saving today at WellRx.com

FAQs related to injections to lose weight

What are the different types of weight loss injections?

The main categories include GLP-1 agonists (Wegovy, Saxenda) and dual GLP-1/GIP agonists (Zepbound, Mounjaro). Each of these popular weight loss injections works through specific mechanisms to control appetite and metabolism while promoting weight loss.

What are some safe weight loss injections?

FDA-approved options include Zepbound, Wegovy, and Saxenda. These medical weight loss injections have undergone extensive clinical trials and are considered safe when prescribed and monitored by healthcare providers.

Are there any over-the-counter weight loss injections?

No FDA-approved over-the-counter weight loss injections exist currently. All effective weight loss shots require a prescription and medical supervision to ensure safety and proper use.

What is the best injection for weight loss at home?

Prescribed medications like Wegovy or Zepbound can be self-administered at home after proper training from your healthcare provider. However, regular medical monitoring is still required.

How does Wegovy help you lose weight?

Wegovy works by mimicking the GLP-1 hormone, which helps reduce appetite, slow digestion, and regulate blood sugar levels. This combination of effects leads to reduced food intake and weight loss.

Do cheap weight loss injections work?

Use caution with "cheap" alternatives. FDA-approved weight loss injections are precisely dosed and regulated. Discounted versions may be counterfeit or unsafe. Always obtain medications through legitimate pharmacies.

How much do daily weight loss injections cost?

Costs typically range from $900-$1,400 per month without insurance. Using ScriptSave® WellRx can help reduce these costs significantly. Check WellRx.com for current pricing and savings opportunities.

Does WellRX offer a coupon for Wegovy?

Yes, ScriptSave® WellRx provides savings opportunities for Wegovy and other weight loss medications. Visit WellRx.com to check current pricing and available discounts.

What are the most affordable weight loss injections?

Using ScriptSave® WellRx can help make various weight loss injections more affordable. Compare prices and available discounts at WellRx.com to find the most cost-effective option for your needs.

What are the side effects of fat loss injections?

Common side effects include nausea, diarrhea, constipation, and injection site reactions. Most side effects are mild and decrease over time as your body adjusts to the medication. Serious side effects are rare but possible. Alyse Thompson, M.D., is a freelance medical writer who has experience caring for patients in both primary care and urgent care settings. She also has a master's degree in basic medical science. She has managed acute and chronic diseases and has taken part in medical and pharmaceutical research. Dr. Thompson's focus has been on surgery, general medicine, weight loss, infectious disease, medical devices, pharmaceutical research, and medical apps.

References

https://www.health.harvard.edu/heart-health/the-new-diabetes-drugs-your-best-shot-for-weight-loss

https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

https://www.ncbi.nlm.nih.gov/books/NBK608007/

https://www.ncbi.nlm.nih.gov/books/NBK279038/

https://medlineplus.gov/ency/article/007199.htm