What Is the Best Fertility Drug to Get Pregnant?

By Libby Pellegrini MMS, PA-C

April 08, 2025

Pregnancy

What is the best fertility drug to get pregnant?

Pregnancy occurs when an egg cell is released from the ovaries (a process called ovulation) and fertilized by a sperm cell. While this sounds like a straightforward process at first, it can be highly complex. Many hormones and other factors influence fertility, and, for many people, conceiving naturally can be very difficult. Fortunately, certain medicines can help ovulation and improve the chances of conception. So, what is the best fertility drug to get pregnant? Read on to learn more about medication to get pregnant.



What is the best fertility drug to get pregnant? 6 common fertility drugs for women

Infertility is defined as the inability to conceive a pregnancy after 12 months of dedicated attempts (or 6 months after age 35). When you are struggling to get pregnant, it can be overwhelming to consider medicine to help ovulation. However, ovulation meds, such as those listed below, can be used very effectively to boost your chances of conceiving.

Medicine Drug Class Common Dosage (Adults) WellRx Savings Card
Letrozole (Femara) Aromatase inhibitor 2.5 mg Link Out
Clomiphene (Clomid, Serophene) Ovarian stimulant 50 mg Link Out
Metformin Antihyperglycemic 500 mg Link Out
CoQ10 Supplement 100 mg Link Out
Bromocriptine Prolactin inhibitor 2.5 mg Link Out
Cabergoline Prolactin inhibitor 0.5 mg Link Out



Who should take fertility drugs?

If you are struggling to conceive, or if you are looking for pills to get pregnant fast, you may be interested in fertility drugs. In general, ovulation pills and fertility pills are helpful if you have a medical condition known as polycystic ovarian syndrome (PCOS), irregular menstrual cycles, or you have a condition of your pituitary gland that affects your fertility. Consulting with a fertility expert can help you understand different fertility treatments as well as the strongest fertility pill.



Types of fertility drugs for women

Medicine for ovulation comes in different forms. For example, some medications are taken in pill form, while others are only available in injectable form. The type of medication that is right for you depends on your particular medical history and fertility history.

Ovarian stimulant drugs

An ovarian stimulant medication helps the body release an egg from the ovaries. This medication can help you get pregnant if you have a history of amenorrhea (no periods) or irregular menstruation. An example of an ovarian stimulant drug is clomiphene (Clomid). These medications are usually considered the “first line” for boosting fertility.

Injectable fertility hormones

This type of medication is often used after a trial of an ovarian stimulant medication. These injections help augment the body’s natural reproductive process using hormones such as LH and FSH. Examples include:

  • Novarel
  • Bravelle
  • Lupron
  • Antagon

Aromatase inhibitors

This medication helps trigger the release of more FSH hormones by blocking the conversion of androgen hormones to estrogen hormones. The increase in FSH helps your body produce and release more egg cells. An example of this medication is Letrozole (Femara).

Prolactin inhibitors

If you have a pituitary condition that increases your production of prolactin hormone, it can reduce your ovulation and interfere with your ability to get pregnant. A prolactin inhibitor, such as cabergoline or bromocriptine, can help improve your fertility by lowering your production of prolactin.



How effective are fertility pills?

Fertility pills can be a very effective way to increase your ability to get pregnant. For example, experts note that using clomiphene to achieve pregnancy can result in a 6-month live birth rate of up to 40%.



Are fertility pills available over the counter?

Currently, no medication to help ovulation is available over the counter. This type of medication induces hormonal changes and should be used carefully in conjunction with a medical provider. However, certain supplements that have been purported to boost pregnancy, such as CoQ10, are available over the counter.



How long does it take for fertility pills to work?

Experts consider the length of time to get pregnant with fertility pills using a framework of menstrual cycles. For example, ovarian stimulants are often evaluated by their ability to induce a chemical pregnancy after 6 cycles of dedicated use. When considering how long it takes for fertility pills to work, it’s helpful to use this 6-month metric. However, your age and particular medical history will influence how long it takes for fertility pills to work.



How to safely take fertility medicine as a female

Taking ovulation pills is safe when done in conjunction with a trained medical provider. However, taking medications that alter your hormone production without the direction of a medical provider can subject you to several problems. Make sure to follow your medical provider’s exact instructions regarding the timing of your fertility medications.



Natural fertility-boosting remedies

Outside of prescription medications, natural remedies and pills that help you get pregnant are available. These include the following:

  • Increasing exercise: If you have a low physical activity level and high sedentary behavior, increasing your exercise frequency may boost your fertility by helping moderate your body weight and hormone levels. However, too much strenuous physical exercise can reduce your ovulation and lower your fertility.
  • Increasing antioxidant foods: Eating a balanced diet of antioxidants may help improve your fertility. Experts have studied the Mediterranean diet for its potential impacts on fertility and have noted that it may positively affect clinical pregnancy rates.
  • Adding supplements: Certain supplements, such as CoQ10 and maca root, may help increase fertility. However, it’s essential to speak with your medical provider before taking any supplementary medicine to help you get pregnant.



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FAQs related to medication to help get pregnant



What is Letrozole used for in fertility?

Letrozole is an ovulation induction agent. It helps stimulate your ovaries to mature egg cells and release them (a process known as “ovulation”).

What is the best alternative to Clomid?

The best alternative to Clomid may be an alternative ovulation induction agent, such as Letrozole. Although Letrozole is not FDA-approved for fertility treatments, it is commonly used by infertility professionals.

What are the best pills to help get pregnant?

The best pills to help you get pregnant are likely ovarian stimulation drugs, such as Clomid and Letrozole. These medications increase the chances of your ovaries releasing a mature egg cell, increasing your chances of conceiving.

What are the best fertility pills to get pregnant with twins?

Ovulation-induction medications, such as Clomid and Letrozole, are associated with a higher rate of multiple pregnancies (twins, triplets, etc.). These medications stimulate the ovaries to produce more mature egg cells, which may be released and fertilized simultaneously.

What is the most potent fertility pill?

The most potent fertility pill, or the strongest fertility pill, may be the one that results in the most live births. With this definition, studies show that Letrozole has the upper hand on Clomid when it comes to helping women who are suffering from anovulatory conditions go on to conceive a pregnancy.

How do fertility pills work?

Fertility drugs work by influencing the hormones that drive your body’s process of ovulation. Therefore, they affect the ovaries to produce more mature egg cells. When you produce and release more egg cells with each cycle, your chances of conceiving a pregnancy increase.

What is the most commonly prescribed infertility treatment for women with polycystic ovary syndrome?

Clomid (clomiphene) is the most commonly prescribed infertility treatment for women with polycystic ovarian syndrome (PCOS). This medicine influences the ovaries to mature and release more egg cells each cycle.

What fertility drugs are there for men?

There are several fertility drugs available for men, including a drug that is often used for women, Clomid. A hormone known as human chorionic gonadotropin (HCG) and a medication called anastrozole can also help improve a man’s testosterone level.

Can I take fertility drugs myself without having to go to a clinic?

No. Because fertility medication to help you get pregnant fast is limited to prescription-only medicines. A provider must see you in a clinic to get a prescription.

Can I get fertility drugs on the NHS?

Yes. These drugs are available on the NHS, provided they have been prescribed to you. In the UK, fertility medications are only available by prescription, so it’s important to have a conversation with your healthcare provider if you are looking for medicine to get pregnant fast.

Which brand of CoQ10 is best for fertility?

Talk to your medical provider to determine which brand of CoQ10 is best for fertility. Taking a supplement is similar to taking any other medication because both are metabolized in similar ways and can have unwanted side effects. If your provider determines that CoQ10 is appropriate, have them direct you to the brand they recommend the most. Libby Pellegrini is a nationally certified physician assistant. She currently works in emergency medicine, where she sees and treats a broad spectrum of illnesses across all age ranges. She holds a journalism degree from Northwestern University.



References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9302705/

https://www.hfea.gov.uk/treatments/explore-all-treatments/fertility-drugs/

https://www.ncbi.nlm.nih.gov/books/NBK559292/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7614776/#:~:text=Among%20women%2C%20increased%20physical%20activity,for%20increased%20likelihood%20of%20conception.&text=In%20contrast%2C%20high%20levels%20of,ovulation%2C%20leading%20to%20decreased%20fertility

https://pmc.ncbi.nlm.nih.gov/articles/PMC11356935/

https://www.nichd.nih.gov/health/topics/pcos/conditioninfo/treatments/infertility#:~:text=Clomiphene%20or%20Clomiphene%20Citrate,infertility%20in%20women%20with%20PCOS.

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