• Image of Medrol Dosepak medication

    • METHYLPREDNISOLONE (Generic for MEDROL)

    • QTY 21
    • 4 MG
    • TAB DS PK

METHYLPREDNISOLONE (meth ill pred NISS oh lone) treats many conditions such as asthma, allergic reactions, arthritis, inflammatory bowel diseases, adrenal, and blood or bone marrow disorders. It works by decreasing inflammation, slowing down an overactive immune system, or replacing cortisol normally made in the body. Cortisol is a hormone that plays an important role in how the body responds to stress, illness, and injury. It belongs to a group of medications called steroids.

METHYLPREDNISOLONE (Generic for MEDROL) Lifestyle Interactions

  • Methylprednisolone 4mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Moderate
    • Notes for Consumers: In theory, grapefruit juice and grapefruits might increase the side effects of Methylprednisolone, but it is not clear if this interaction is significant. If possible, avoid ingesting grapefruit juice while taking Methylprednisolone. At the very least, do not significantly change your daily intake of grapefruit and grapefruit juice.
    • Notes for Professionals: Grapefruit juice may enhance steroid effects if taken with oral methylprednisolone. Grapefruit juice contains a compound that inhibits CYP3A4 in enterocytes; decreased methylprednisolone metabolism is the probable mechanism. Methylprednisolone peak concentrations and AUC increased and the half-life of methylprednisolone was prolonged in one study of the interaction. The clinical significance of the interaction is uncertain. Patients should be advised to not significantly alter their grapefruit juice ingestion.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.