LITFULO Lifestyle Interactions

  • Tezacaftor 100mg, Ivacaftor 150mg, Oral tablet

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take Ivacaftor and grapefruit juice or Seville oranges together. Grapefruit juice and Seville oranges may increase the amount of Ivacaftor in your blood. Side effects from Ivacaftor may get worse if you use grapefruit juice or Seville oranges. Notify your prescriber if you have any new or worsening side effects.
    • Notes for Professionals: The manufacturer recommends avoiding grapefruit or Seville oranges during ivacaftor therapy because ivacaftor exposure may be increased. Ivacaftor is a CYP3A substrate. Grapefruit juice and Seville oranges contain components that inhibit CYP3A, and therefore, may reduce ivacaftor metabolism.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.