LAMISIL

Terbinafine Hydrochloride 1%, Topical spray, solution

Caffeine-containing Foods/Beverages

· Severity: Mild

· Notes for Consumers: Side effects from Caffeine may get worse if you take Terbinafine tablets. You may need to limit your Caffeine intake while receiving Terbinafine tablets. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Terbinafine skin creams do not interact.

· Notes for Professionals: Terbinafine has been shown to inhibit the clearance of caffeine. The clinical significance of this interaction has not been determined.

Terbinafine Hydrochloride 1%, Topical spray, solution

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together with caution. Taking these drugs together may increase the risk for side effects. If your doctor decides that taking these drugs together is right for your condition, you will be closely monitored. Immediately report any new or worsening side effects to your health care provider.

· Notes for Professionals: Due to the risk for terbinafine related adverse effects, caution is advised when coadministering grapefruit juice. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, administration may increase the systemic exposure of terbinafine. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9 and CYP3A4; grapefruit juice is an inhibitor of these enzymes. Monitor patients for adverse reactions.

Terbinafine Hydrochloride 1%, Topical spray, solution

Tobacco

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together with caution. Taking these drugs together may decrease the effectiveness of terbinafine. If your doctor decides that taking these drugs together is right for your condition, you will be closely monitored. Immediately contact your health care provider if your medicines do not seem to be working as well for you.

· Notes for Professionals: Due to the risk for breakthrough fungal infections, caution is advised when administering terbinafine to someone who smokes tobacco. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, administration may decrease the systemic exposure of terbinafine. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP1A2; tobacco smoking induces this enzyme. Monitor patients for breakthrough fungal infections.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>