KRAZATI Lifestyle Interactions

  • Selumetinib 10mg, Oral capsule

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Selumetinib together without talking to your health care professional. Side effects from Selumetinib may get worse if you take Grapefruit Juice or grapefruit-containing foods. Contact your health care provider if you experience mouth sores, diarrhea, unusual tiredness or weakness, muscle or bone pain, shortness of breath, swelling in your ankles or feet, changes in vision, or other new or unusual side effects.
    • Notes for Professionals: Advise patients to avoid grapefruit juice or grapefruit-containing foods during use of selumetinib due to the risk of increased selumetinib exposure which may increase the risk of adverse reactions. Selumetinib is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased selumetinib exposure by 49%.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.