GEMFIBROZIL (Generic for LOPID)

Gemfibrozil 600mg, Oral tablet

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: Use caution if coadministration of marijuana with gemfibrozil is necessary and monitor for an increase in marijuana-related adverse reactions (e.g., feeling high, dizziness, confusion, somnolence). Of the over 70 phytocannabinoids in marijuana, delta9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannibinol are the 3 main constituents. Certain cannabionoids are CYP2C9 and 3A4 substrates; gemfibrozil is a weak inhibitor of CYP2C9. Concomitant use may result in elevated plasma concentrations of certain cannabinoids found in marijuana.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>